PUTATIVE NULL DISTRIBUTIONS CORRESPONDING TO TESTS OF DIFFERENTIAL EXPRESSION IN THE GOLDEN SPIKE DATASET ARE INTENSITY DEPENDENT

Putative null distributions corresponding to tests of differential expression in the Golden Spike dataset are intensity dependent

Abstract Background We provide a re-analysis of the Golden Spike dataset, a first generation "spike-in" control microarray dataset.The original analysis of the Golden Spike dataset was presented in a manuscript by Choe et al.and raised questions concerning the performance of several statistical methods for the control of the false discovery rate (a

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Pathophysiology of a scientific paper

Scientific paper writing for science journals is highly adroit, competitive, and laborious process.Scientific writing has a constant design, which is confounding for apprentice science writers.The huge amount of impediments is associated with scientific TOOTHPASTE FENNEL writing which may be reduced by applying some practices and guidelines.The bas

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Microdissection Testicular Sperm Extraction (micro-TESE) as a Sperm Acquisition Method for Men with Nonobstructive Azoospermia Seeking Fertility: Operative and Laboratory Aspects

Introduction Rare foci of sperm production may be found in up to 60% of men with nonobstructive azoospermia (NOA).Sperm production, if present, is minimal for sperm appearance in the ejaculate.Given that there are no treatment options to restore fertility, sperm retrieval is the only alternative to find testicular sperm than then can be used for in

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